Scientific Studies which Support Ultra Prime™ Secretagogue HGH Enhancer:
Abdelhamed AI, Reis SE, Sane DC, et al. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J. 2003.;145:E15. AHFS Drug Information. Bethesda, Md: American Society of Hospital Pharmacists. 2000:2306–2307. Akobeng AK, Miller V, Stanton J, et al. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. J Pediatr Gastroenterol Nutr . 2000; 30:78–84. Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr .1990; 14(suppl 4):109S–113S. Baecker N, Boese A, Schoenau E et al. L-Arginine, the Natural Precursor of NO, Is Not Effective for Preventing Bone Loss in Postmenopausal Women. J Bone Miner Res. 2005; 20:471-9. Baligan M, Giardina A, Giovannini G, et al. L-arginine and immunity. Study of pediatric subjects [translated from Italian]. Minerva Pediatr . 1997; 49:537–542. Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod. 1999; 14:1690–1697. Beale R, Bryg D, Bihari D. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med. 1999; 27:2799–2805. Bednarz B, Jaxa-Chamiec T, Maciejewski P et al. Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol Pol. 2005; 62:421-427. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol . 2000; 75:205–210. Boger RH, Bode-Boger SM, Thiele W, et al. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998; 32:1336–1344. Bruinsma KA, Anderson BE, Prendergast JJ, et al. Effects of an L-arginine-enriched medical food in patients with type II diabetes [abstract]. Diabetes. 2001; 50(suppl 2):Abst #1796-PO. Buckley, Abbott, Martin, Brinkworth & Whyte Effect of an oral bovine colostrum supplement (intact TM ) on running performance. Abstract from: 1998 Australian Conference of Science and Medicine in Sport, Adelaide, South Australia, October 1998. Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol. 1998; 76:524–532. Castell LM, Newsholme EA. The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition. 1997; 13:738–742. Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol Occup Physiol. 1996; 73:488–490. Chen J, Wollman Y, Chernichovsky T, et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized placebo-controlled study. BJU Int. 1999; 83:269–273. Civitelli R, Villareal DT, Agnusedei D, et al. Dietary L-lysine and calcium metabolism in humans. Nutrition . 1992; 8:400-405. Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr . 2000; 24:133–139. Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut. 2001;48:28–33. De Aloysio D, Mantuano R, Mauloni M, et al. The clinical use of arginine aspartate in male infertility. Acta Eur Fertil . 1982; 13:133–167. de Gouw HW, Verbruggen MB, Twiss IM, et al. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax. 1999; 54:1033-1035. de Koning TJ, Duran M, Dorland L, et al. Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. Ann Neurol . 1998; 44:261–265. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int. 1999; 56:674–684. Den Hond E, Hiele M, Peeters M, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. JPEN J Parenter Enteral Nutr . 1999; 23:7–11. Di Giovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol . 1984; 120:48-51. Diaz P, Bhaskara S, Dursun SM et al. Double-blind, Placebo-Controlled, Crossover Trial of Clozapine Plus Glycine in Refractory Schizophrenia Negative Results. J Clin Psychopharmacol . 2005; 25:277-278. Evins AE, Fitzgerald SM, Wine L, et al. Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry . 2000; 157:826-828. File SE, Fluck E, Fernandes C. Beneficial effects of glycine (Bioglycin) on memory and attention in young and middle-aged adults. J Clin Psychopharmacol . 1999; 19:506–512. Flondin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am Coll Nutr. 1997; 16:7-21. Fox AD, Kripke SA, Berman JR, et al. Reduction of the severity of enterocolitis by glutamine-supplemented enteral diets. Surg Forum . 1987; 38:43–44. Fries MH, Rinaldo P, Schmidt-Sommerfeld E, et al. Isovaleric acidemia: response to a leucine load after three weeks of supplementation with glycine, L-carnitine, and combined glycine-carnitine therapy. J Pediatr . 1996; 129:449–452. Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg . 1995; 82:749–751. Garcia-de-Lorenzo A, Zarazaga A, Garcia-Luna PP, et al. Clinical evidence for enteral nutritional support with glutamine: a systematic review. Nutrition . 2003; 19:805-11. Grasemann H, Grasemann C, Kurtz F, et al. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur Respir J . 2005; 25:62-8. Greenberg and Cello. 1996. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulins concentrate in patients with AIDS. J. AIDS and Hum. Retrovirol. 13:348-354. Griffith RS, De Long DC, Nelson JD. Relation of L-arginine—lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 1981; 27:209-213. Griffith RS, DeLong DC, Nelson J. Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture. Chemotherapy. 1981; 27:209–213. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica . 1987; 175:183-190. Griffiths RD, Jones C, Palmer TE. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition . 1997; 13:295–302. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis . 2000; 10:49–60. Hambrecht R, Hilbrich L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol. 2000; 35:706–713. Harvey SG, Gibson JR, Burke CA. L-cysteine, glycine and dl-threonine in the treatment of hypostatic leg ulceration: a placebo-controlled study. Pharmatherapeutica . 1985; 4:227–230. Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004; 55:165-71. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry . 1999; 56:29–36. Huffman FG, Walgren ME. L-Glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV Clin Trials . 2003; 4:324-9. Itoh T, Ito T, Ohba S, et al. Effect of carnitine administration on glycine metabolism in patients with isovaleric acidemia: significance of acetylcarnitine determination to estimate the proper carnitine dose. Tohoku JExp Med . 1996; 179:101–109. Javitt DC, Balla A, Sershen H, et al. A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors. Biol Psychiatry . 1999; 45:668–679. Javitt DC, Zylberman I, Zukin SR, et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry . 1994; 151:1234–1236. Javitt DC. Management of negative symptoms of schizophrenia. Curr Psychiatry Rep . 2001; 3:413-417. Kelly, Chetham, Keates, Bostwick, Roush, Castagliuolo, LaMont and Pothoulakis. 1997. Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract. Antimicrobial Agents and Chemother. 41;236-241. Kelly, Pothoulakis, Vavva, Castagliuolo, Bostwick, O'Keane, Keates and LaMont. 1996. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins. Antimicrobial Agents and Chemother. 40:373-379. Khan F, Litchfield SJ, McLaren M, et al. Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum . 1997; 40:352–357. Khogali SE, Pringle SD, Weryk BV, et al. Is glutamine beneficial in ischemic heart disease? Nutrition. 2002; 18:123–126. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999; 161:558–565. Lebret T, Herve JM, Gorny P, et al. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. 2002; 41:608-613. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointestinal nephritis in association with L-lysine ingestion. Am J Kidney Dis. 1996; 28:614-617. Luiking YC, Weusten BL, Portincasa P, et al. Effects of long-term oral L-arginine on esophageal motility and gallbladder dynamics in healthy humans. Am J Physiol . 1998;274(6 pt 1):G984–G991. Mackinnon LT, Hooper SL. Plasma glutamine and upper respiratory tract infection during intensified training in swimmers. Med Sci Sports Exerc. 1996;28:285–290. Mansoor JK, Morrissey BM, Walby WF et al. L-Arginine Supplementation Enhances Exhaled NO, Breath Condensate VEGF, and Headache at 4342 m. High Alt Med Biol. 2005;6:289-300. Martinez-Abundis E, Kam-Ramos AM, Hernandez-Salazar E, Gonzalez-Ortiz. Effect of glycine on insulin secretion, fasting and postprandial glucose levels in patients with type 2 diabetes mellitus. 18th International Diabetes Federation Congress, Paris, August 24-29, 2003;abstract 758. Maxwell A. Annual meeting of American College of Cardiology, 1999. Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med. 2000;5(1):11-9. Maxwell AJ, Zapien MP, Pearce GL, et al. Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol . 2002; 39:37–45. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis . 1984; 34:366-373. Mebane AH. L-Glutamine and mania [letter]. Am J Psychiatry. 1984; 141:1302–1303. Mero, A., Miikkulainen, H., Riski, J., Pakkanen, R., Aalto, J., Takala, T. (1997). Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone and saliva IgA during training. J. Appl. Physiol. 83(4): 1144-1151. Meston CM, Worcel M. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002; 31:323-332. Meston CM, Worcel M. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002; 31:323-332. Moriguti JC, Ferriolli E, Donadi EA et al. Effects of arginine supplementation on the humoral and innate immune response of older people. Eur J Clin Nutr. 2005 Jul 27 [Epub ahead of print]. Morris CR, Morris Jr. SM, Hagar W, et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med . 2003; 168:63-9. Mroueh A. Effect of arginine on oligospermia. Fertil Steril . 1970; 21:217–219. Parker JO, Parker JD, Caldwell RW, et al. The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy. J Am Coll Cardiol. 2002;39:1199-1203. Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875–880. Playford RJ, Floyd DN, Macdonald CE, Calnan DP , Adenekan RO, Johnson W, Goodlad RA, Marchbank T. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut 1999 May: 44(5): 653-8. Potkin SG, Jin Y, Bunney BG, et al. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry . 1999; 156:145–147. Pryor JP, Blandy JP, Evans P, et al. Controlled clinical trial of arginine for infertile men with oligozoospermia. Br J Urol. 1978; 50:47-50. Quan ZF, Yang C, Li N, Li JS. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J Gastroenterol . 2004; 10:1992-4. Rajamohan T, Kurup PA. Lysine: arginine ratio of a protein influences cholesterol metabolism: Part 1-studies on sesame protein having low lysine: arginine ratio. Indian J Exp Biol . 1997; 35:1218-1223. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation . 1996; 93:2135–2141. Rohde T, MacLean DA, Hartkopp A, et al. The immune system and serum glutamine during a triathlon. Eur J Appl Physiol . 1996; 74:428–434. Rose ML, Cattley RC, Dunn C, et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14, 643. Carcinogenesis . 1999; 20:2075–2081. Rowbottom DG, Keast D, Morton AR, et al. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med . 1996; 21:80–97. Rytlewski K, Olszanecki R, Korbut R et al. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest. 2005; 35:32-7. Schachter A, Friedman S, Goldman JA, et al. Treatment of oligospermia with the amino acid arginine. Int J Gynaecol Obstet. 1973; 11:206–209. Schulman SP, Becker LC, Kass DA, et al. L-Arginine therapy in acute myocardial infarction. The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006; 295(1): 58-64. Semba J. Glycine therapy of schizophrenia; its rationale and a review of clinical trials [translated from Japanese]. Nihon Shinkei Seishin Yakurigaku Zasshi . 1998; 18:71–80. Shabert JK, Winslow C, Lacey JM, et al. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition . 1999; 15:860–864. Sopala M, Schweizer S, Schafer N, et al. Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats. Arzneimittelforschung . 2002; 52:168-74. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand . 2004; 83:103-7. Tacket, Binion, Bostwick, Losonsky, Roy and Edelman. 1992. Efficacy of bovine milk immunoglobulins concentrate in preventing illness after Shigella flexneri challenge. Amer. J. Trop. Med. Hyg. 47:276-283. Takahashi, Eisenhuth, Lee, Schachtele, Laible and Binion. 1992. Nonspecific antibacterial factors in milk from cows immunized with human oral bacterial pathogens. J. Dairy Sci. 75:1810-1820. Tanimura J. Studies on arginine in human semen. II. The effects of medication with L-arginine-HCl on male infertility. Bull Osaka Med Sch . 1967; 13:84–89. Tatlisumak T, Takano K, Meiler MR, Fisher M. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir Suppl . 2000; 76:331-333. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol. 1984; 58:659-666. Thurman RG, Zhong Z, von Frankenberg M, et al. Prevention of cyclosporine-induced nephrotoxicity with dietary glycine. Transplantation . 1997;63:1661–1667. Tollemar, Gross, Dolgiras, Jarstrand, Ringdén and Hammarström. 1999. Fungal prophylaxis by reduction of fungal colonization by oral administration of bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow Transpl. 23:283-290. van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet . 1993; 341:1363–1365. Warny, Fatimi, Bostwick, Laine, Lebel, LaMont, Pothoulakis, Kelly. 1999. Bovine immunoglobulins concentrate-Clostridium difficile retains C. difficile toxin neutralizing activity after passage through the human stomach and small intestine. Gut 44:212-217. Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens. 2000;18:229–234. Yin M, Ikejima K, Arteel GE, et al. Glycine accelerates recovery from alcohol-induced liver injury. J Pharmacol Exp Ther . 1998; 286:1014–1019. Zhong Z, Arteel GE, Connor HD, et al. Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am J Physiol . 1998;275:F595–RF604. Zoli G, Care M, Falco F, et al. Effect of oral glutamine on intestinal permeability and nutritional status in Crohn's disease [abstract]. Gastroenterology . 1995;108:A766.